It would help quite a bit. Obviously, if the grade is so steep that it requires a first gear at 15MPH, I'm not sure how much quicker you would be able to pull it with the tuning installed but likely it would not require 1st gear anymore.
Hi James,
I would say just start with the tuner your coach falls under this listing 2006-Current 2v V10 Gains of 43 HP and 47 ft-lb Torque (E-Series) this will be a significant increase in power and also reduce downshifting. Headers are great, but the labor on install for that engine in a C-Class is huge! If you do decide you want more after the tune, and decide to install the headers then it is an easy change to the tune to accommodate for them.