Yes we have dyno'd several 8.1L/4L80E combo's but mostly in the P32 Workhorse configuration. Results are very similar to what we see with the 8.1L/Allison. We do not state that a higher octane fuel is required, we tune for 87 octane but CAN tune for a higher octane if desired. No pinging or knocking as long as your engine and sensors are healthy :)
The crankshaft relearn will require a scan tool but only takes a minute or two to complete. The Passkey relearn is a fairly lengthy process (~30 minutes) but is very easy, we can send instructions on this if needed.